Kanika Khanna, et al. Herbal immune-boosters: Substantial warriors of pandemic Covid-19 battle. Phytomedicine,

Levy E, Delvin E, Marcil V, Spahis S. Can phytotherapy with Polyphenols serve as a powerful approach for the prevention and therapy tool of novel coronavirus disease 2019 (COVID-19)? Am J Physiol Endocrinol Metab 319: E689–E708, 2020.

Quiles JL et al. Do nutrients and other bioactive molecules from foods have anything to say in the treatment against COVID-19? Environmental Research 191 (2020) 110053

Ananda da Silva Antonio, Larissa Silveira Moreira Wiedemann and Valdir Florencio Veiga-Junior. Natural products‘ role against COVID-19. RSC Adv., 2020, 10, 23379–23393

Thota SM, Balan V, Sivaramakrishnan V. Natural products as home-based prophylactic and symptom management agents in the setting of COVID-19. Phytotherapy Research. 2020;1–20.


Arslan, Bengu and Ucuncu Ergun, Nurcan and Topuz, Seyma and Yilmaz Semerci, Seda and Suner, Nurettin and Kocatas, Ali and Onal, Hasan, Synergistic Effect of Quercetin and Vitamin C Against COVID-19: Is a Possible Guard for Front Liners. Available at SSRN: or

Derosa G, Maffioli P, D’Angelo A, Di Pierro F. A role for Quercetin in coronavirus disease 2019 (COVID-19). Phytotherapy Research. 2020;1–7.

Agrawal PK , Agrawal Ch, and Blunden G. Quercetin: Antiviral Significance and Possible COVID-19 Integrative Considerations Flavonoids and Related Compounds as Natural Products-Review. Natural Product Communications: Volume 15(12): 1–10

Anwar E, Soliman M, Darwish S, et al. Mechanistic Similarity of Immuno-modulatory and Anti-viral Effects of Chloroquine and Quercetin (The Naturally Occurring Flavonoid). Clin Immunol Res. 2020; 4(1): 1-6.

Abian O et al. Structural stability of SARS-CoV-2 3CLpro and identification of Quercetin as an inhibitor by experimental screening. International Journal of Biological Macromolecules 164 (2020) 1693–1703

Pandey P, Rane JS, Chatterjee A, et al. Targeting SARS-CoV-2 spike protein of COVID-19 with naturally occurring phytochemicals: an in silico study for drug development [published online ahead of print, 2020 Jul 22]. J Biomol Struct Dyn. 2020;1-11. doi:10.1080/07391102.2020.1796811

Wu W, Li R, Li X, et al. Quercetin as an Antiviral Agent Inhibits Influenza A Virus (IAV) Entry. Viruses. 2015;8(1):6. Published 2015 Dec 25. doi:10.3390/v8010006


Jennings Morgan R, Parks Robin J. Review: Curcumin as an Antiviral Agent. Viruses 2020, 12, 1242; 1-15, doi:10.3390/v12111242

Weerasinghe Priya et al. Molecular Mechanisms of Curcumin in COVID-19 Treatment and Prevention: A Global Health Perspective Medical Research Archives vol 8 issue 10. October 2020: 1-22

Liu Z and Ying Y (2020) The Inhibitory Effect of Curcumin on Virus-Induced Cytokine Storm and Its Potential Use in the Associated Severe Pneumonia. Front. Cell Dev. Biol. 8:479. doi: 10.3389/fcell.2020.00479

Nemati M, Asl ER, Pouya FD, Rasmi Y. Curcumin, an Inhibitor of PAK1, Potential Treatment for COVID-19. J Infectiology. 2020; 3(2): 1-3

Manoharan Y, Haridas V, Vasanthakumar KC, Muthu S, Thavoorullah FF, Shetty P. Curcumin: a Wonder Drug as a Preventive Measure for COVID19 Management. Ind J Clin Biochem (July-Sept 2020) 35(3):373–375

Saeedi-Boroujeni A et al. COVID-19: A Case for Inhibiting NLRP3 Inflammasome, Suppression of Inflammation with Curcumin? Basic Clin Pharmacol Toxicol. 2020;00:1–9.

Hosseinzadeh H. Curcumin (a constituent of turmeric): New treatment option against COVID-19. Food Sci Nutr. 2020;8:5215–5227.

Imtiaz Taanya et al. Curcumin A Better Medicine to Treat Coronavirus – A Review. Indian Journal of Forensic Medicine & Toxicology, October-December 2020, Vol. 14, No. 4: 4630-4638

Zahedipour F, Hosseini SA, Sathyapalan T, et al. Potential effects of Curcumin in the treatment of COVID-19 infection. Phytotherapy esearch. 2020;1–10.

Francisco Rocha, Marcos de Assis. Turmeric against Covid-19: too much of a coincidence? Authorea. April 15, 2020. DOI:10.22541/au.158696104.40782844


R. Ghosh, A. Chakraborty, A. Biswas, and S. Chowdhuri, Evaluation of Green tea Polyphenols as novel corona virus (SARS CoV-2) main protease (Mpro) inhibitors-an in silico docking and molecular dynamics simulation study. Journal of Biomolecular Structure and Dynamics, vol. 760, pp. 1–13, 2020.

Susmit Mhatre et al. Antiviral activity of Green tea and Black tea Polyphenols in prophylaxis and treatment of COVID-19: A review. Phytomedicine,

Jang M et al. Tea Polyphenols EGCG and Theaflavin Inhibit the Activity of SARS-CoV-2 3CL-Protease In Vitro. Hindawi Evidence-Based Complementary and Alternative Medicine Volume 2020, Article ID 5630838, 7 pages,

Menegazzi, M.; Campagnari, R.; Bertoldi, M.; Crupi, R.; Di Paola, R.; Cuzzocrea, S. Protective Effect of Epigallocatechin-3-Gallate (EGCG) in Diseases with Uncontrolled Immune Activation: Could Such a Scenario Be Helpful to Counteract COVID-19? Int. J. Mol. Sci. 2020, 21, 5171.

Maiti, S.; Banerjee, A. Epigallocatechin-Gallate and Theaflavin-Gallate Interaction in SARS CoV-2 Spike-Protein Central-Channel with Reference to the Hydroxychloroquine Interaction: Bioinformatics and Molecular Docking Study. Preprints 2020, 2020040247 (doi: 10.20944/preprints202004.0247.v1).

The HERD Study – Protection of HEalth workeRs against coviD-19. Retrieved from (December 18, 2020)

Furushima D, Nishimura T, Takuma N, Iketani R, Mizuno T, Matsui Y, Yamaguchi T, Nakashima Y, Yamamoto S, Hibi M, Yamada H. Prevention of Acute Upper Respiratory Infections by Consumption of Catechins in Healthcare Workers: A Randomized, Placebo-Controlled Trial. Nutrients. 2019 Dec 18;12(1):4. doi: 10.3390/nu12010004.


Murck H (2020) Symptomatic Protective Action of Glycyrrhizin (Licorice) in COVID-19 Infection? Front. Immunol. 11:1239. doi: 10.3389/fimmu.2020.01239

Chrzanowski J, Chrzanowska A, Grabon W. Glycyrrhizin: An old weapon against a novel coronavirus. Phytotherapy Research. 2020;1–8.

Bailly C, Vergoten G. Glycyrrhizin: An alternative drug for the treatment of COVID-19 infection and the associated respiratory syndrome? Pharmacology & Therapeutics 214 (2020) 107618

Shaopeng Yu, Glycyrrhizic acid exerts inhibitory activity against the spike protein of SARS-CoV-2. Phytomedicine,

SIinha SK et al. Identification of bioactive compounds from Glycyrrhiza glabra as possible inhibitor of SARS-CoV-2 spike glycoprotein and non-structural protein-15: a pharmacoinformatics study. JOURNAL OF BIOMOLECULAR STRUCTURE AND DYNAMICS .


Dudhatra GB et al. A Comprehensive Review on Pharmacotherapeutics of Herbal Bioenhancers The Scientific World Journal Volume 2012, Article ID 637953, 33 pages, doi:10.1100/2012/637953

Prassan Ch et al. Computational studies reveal Piperine, the predominant oleoresin of black pepper (Piper nigrum) as a potential inhibitor of SARS-CoV-2 (COVID-19). Current Science (00113891) . 10/25/2020, Vol. 119 Issue 8, p1333-1342. 10p.

Rout, Janmejaya; Swain, Bikash Chandra; Tripathy, Umakanta (2020): In Silico Investigation of Spice Molecules as Potent Inhibitor of SARS-CoV-2. ChemRxiv. Preprint.


Pal, A., Squitti, R., Picozza, M. et al. Zinc and COVID-19: Basis of Current Clinical Trials. Biol Trace Elem Res (2020).

Mossink JP. Zinc as nutritional intervention and prevention measure for COVID-19 disease. BMJ Nutr Prev Health. 2020;3(1):111-117. Published 2020 Jun 17. doi:10.1136/bmjnph-2020-000095

Jothimani D, Kailasam E, Danielraj S, Nallathambi B, Ramachandran H, Sekar P, Manoharan S, Ramani V, Narasimhan G, Kaliamoorthy I, Rela M. COVID-19: Poor outcomes in patients with Zinc deficiency. Int J Infect Dis. 2020 Nov;100:343-349. doi: 10.1016/j.ijid.2020.09.014. Epub 2020 Sep 10.

Tayyib, N. A., Ramaiah, P., Alsolami, F. J., & Alshmemri, M. S. (2020). Immunomodulatory Effects of Zinc as a Supportive Strategies for COVID-19. Journal of Pharmaceutical Research International, 32(13), 14-22.

Moseley, H. N. B. (2020, April 12). Current Evidence Supporting the Use of Orally Administered Zinc in the Treatment of COVID-19.


Zhang J et al. Selenium and selenoproteins in viral infection with potential relevance to COVID-19. Redox Biology 37 (2020) 101715

Taylor EW and Radding W (2020) Understanding Selenium and Glutathione as Antiviral Factors in COVID-19: Does the Viral Mpro Protease Target Host Selenoproteins and Glutathione Synthesis? Front. Nutr. 7:143.doi: 10.3389/fnut.2020.00143

Bermano G et al. Selenium and viral infection: are there lessons for COVID-19? British Journal of Nutrition, pages 1-10, doi:10.1017/S0007114520003128

Moghaddam A et al. Selenium Deficiency Is Associated with Mortality Risk from COVID-19. Nutrients 2020, 12, 2098; doi:10.3390/nu12072098

Hiffler L and Rakotoambinina B (2020) Selenium and RNA Virus Interactions: Potential Implications for SARS-CoV-2 Infection (COVID-19). Front. Nutr. 7:164.doi: 10.3389/fnut.2020.00164


Grant WB, Lahore H, McDonnell SL, Baggerly CA, French CB, Aliano JL, Bhattoa HP. Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths. Nutrients. 2020 Apr 2;12(4):988. doi: 10.3390/nu12040988.

Ferder L, Martín Giménez VM, Inserra F, Tajer C, Antonietti L, Mariani J, Manucha W. Vitamin D supplementation as a rational pharmacological approach in the COVID-19 pandemic. Am J Physiol Lung Cell Mol Physiol. 2020 Dec 1;319(6):L941-L948. doi: 10.1152/ajplung.00186.2020. Epub 2020 Sep 30.

Pereira M, Dantas Damascena A, Galvão Azevedo LM, de Almeida Oliveira T, da Mota Santana J. Vitamin D deficiency aggravates COVID-19: systematic review and meta-analysis. Crit Rev Food Sci Nutr. 2020 Nov 4:1-9. doi: 10.1080/10408398.2020.1841090. Epub ahead of print.

Maghbooli Z, Sahraian MA, Ebrahimi M, Pazoki M, Kafan S, Tabriz HM, Hadadi A, Montazeri M, Nasiri M, Shirvani A, Holick MF. Vitamin D sufficiency, a serum 25-hydroxyvitamin D at least 30 ng/mL reduced risk for adverse clinical outcomes in patients with COVID-19 infection. PLoS One. 2020 Sep 25;15(9):e0239799. doi: 10.1371/journal.pone.0239799.

Kara M, Ekiz T, Ricci V, Kara Ö, Chang KV, Özçakar L. ‚Scientific Strabismus‘ or two related pandemics: coronavirus disease and Vitamin D deficiency. Br J Nutr. 2020 Oct 14;124(7):736-741. doi: 10.1017/S0007114520001749. Epub 2020 May 12.


Feyaerts AF, Luyten W. Vitamin C as prophylaxis and adjunctive medical treatment for COVID-19? Nutrition. 2020 Nov-Dec;79-80:110948. doi: 10.1016/j.nut.2020.110948.

Carr AC, Rowe S. The Emerging Role of Vitamin C in the Prevention and Treatment of COVID-19. Nutrients. 2020 Oct 27;12(11):3286. doi: 10.3390/nu12113286.

Gregory Patterson,Carlos M. Isales,Sadanand Fulzele. Low level of Vitamin C and dysregulation of Vitamin C transporter might be involved in the severity of COVID-19 Infection[J]. Aging and disease, 10.14336/AD.2020.0918


Kandeel M, Al-Nazawi M. Virtual screening and repurposing of FDA approved drugs (Ribavirin, Telbivudine, Vitamin B3 – Nicotinamide, Vitamin B12 – Cyanocobalamin, and others) against COVID-19 main protease. Life Sciences, Volume 251, 2020, 117627,

Badawy Abdulla A.-B.. Immunotherapy of COVID-19 with poly (ADP-ribose) polymerase inhibitors: starting with nicotinamide. Bioscience Reports (2020) 40 BSR20202856

Serseg T, Benarous K, Yousfi M. Hispidin and Lepidine E: two Natural Compounds and Folic acid as Potential Inhibitors of 2019-novel coronavirus Main Protease (2019-nCoVMpro), molecular docking and SAR study. Curr Comput Aided Drug Des. 2020 Apr 21. doi: 10.2174/1573409916666200422075440. Epub ahead of print. PMID: 32321407.

Sheybani Z, Dokoohaki MH, Negahdaripour M, et al. The Role of Folic Acid in the Management of Respiratory Disease Caused by COVID-19. ChemRxiv; 2020. DOI: 10.26434/chemrxiv.12034980.v1.

Lopes MJS. (2020). Can Vitamin B12 be an adjuvant to COVID-19 treatment? GSC Biological and Pharmaceutical Sciences, 11(3), 01-05.

Narayanan N, Nair DT. Vitamin B12 may inhibit RNA-dependent-RNA polymerase activity of nsp12 from the SARS-CoV-2virus. IUBMB Life. 2020;72:2112–2120.


Dabbagh-Bazarbachi H, Gael C, Isabel MQ, Mayreli O, Ciara KOH, et al. (2014) “Zinc ionophore activity of Quercetin and Epigallocatechin Gallate: from Hepa 1-6 cells to a liposome model.” J Agric Food Chem. 62: 8085-8093. Link:

Marik Paul, Eastern Virginia Medical School, Norfolk, VA, Critical Care COVID-19 Management Protocol, dokument dostupný na

Polansky Hanan, Lori Gillad. Coronavirus disease 2019 (COVID-19): first indication of efficacy of Gene-Eden-VIR/Novirin in SARS-CoV-2 infection. Letter to the Editor / International Journal of Antimicrobial Agents 55 (2020) 105971

Roy A, Sarkar B, Celik C, et al. Can concomitant use of Zinc and Curcumin with other immunity-boosting nutraceuticals be the arsenal against COVID-19?. Phytother Res. 2020;34(10):2425-2428. doi:10.1002/ptr.6766

Glinsky Gennadi. Tripartite Combination of Candidate Pandemic Mitigation Agents: Vitamin D, Quercetin, and Estradiol Manifest Properties of Medicinal Agents for Targeted Mitigation of the COVID-19 Pandemic Defined by Genomics-Guided Tracing of SARS-CoV-2 Targets in Human Cells Biomedicines 2020, 8, 129; doi:10.3390/biomedicines8050129

Motohashi Noboru, Vanam Anuradha, Gollapudi Rao. In Silico Study of Curcumin and Folic Acid as Potent Inhibitors of Human Transmembrane Protease Serine 2 in the Treatment of COVID-19. INNOSC Theranostics and Pharmacological Sciences 2020 Vol. 3 (No. 2) pp: 3-9

Chen L et al. A Novel Combination of Vitamin C, Curcumin and Glycyrrhizic Acid Potentially Regulates Immune and Inflammatory Response Associated with Coronavirus Infections: A Perspective from System. Biology Analysis. Nutrients 2020, 12, 1193; doi:10.3390/nu12041193

Bakare, T A., and Soar, J. S. A cost-effective preventative approach to potentially save lives in the coronavirus pandemic, jointly using Vitamin D, Curcumin, and Vitamin C, (with updated dosage parameters). DOI:10.35543/

Colunga Biancatelli RML, Berrill M, Catravas JD and Marik PE (2020) Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19). Front. Immunol. 11:1451. doi: 10.3389/fimmu.2020.01451

Gonzalez-Paz, Lenin A., et al. Theoretical molecular docking study of the structural disruption of the viral 3CL-protease of COVID19 induced by binding of Capsaicin, Piperine and Curcumin part 1: A comparative study with chloroquine and hydrochloroquine two antimalaric drugs. (2020).

Rong Li, KaWu, Yu Li, Xiao Liang, Keng Po Lai and Jian Chen. Integrative pharmacological mechanism of Vitamin C combined with Glycyrrhizic acid against COVID-19: findings of bioinformatics analyses. Briefings in Bioinformatics, 00(00), 2020, 1–14

Alexander J et al. Early Nutritional Interventions with Zinc, Selenium and Vitamin D for Raising Anti-Viral Resistance Against Progressive COVID-19. Nutrients 2020, 12, 2358; doi:10.3390/nu12082358

Shakoor, Hira; Feehan, Jack; Al Dhaheri, Ayesha S.; and Ali, Habiba I., „Immune-boosting role of Vitamins D, C, E, Zinc, Selenium and omega-3 fatty acids: Could they help against COVID-19?“ (2020). Books and Book Chapters. 5.

Shoba G et al. Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers. Planta Med 1998; 64(4): 353-356, DOI: 10.1055/s-2006-957450

Chuen Wen Tan , Liam Pock Ho , Shirin Kalimuddin , Benjamin Pei Zhi Cherng , Yii Ean Teh , Siew Yee Thien , Hei Man Wong , Paul Jie Wen Tern , Manju Chandran , Jason Wai Mun Chay , Chandramouli Nagarajan , Rehena Sultana , Jenny Guek Hong Low , Heng Joo Ng , A cohort study to evaluate the effect of combination Vitamin D, Magnesium and Vitamin B12 on progression to severe outcome in older COVID-19 patients, Nutrition (2020), doi:

Ahmed AK, Albalawi YS, Shora HA, Abdelseed HK, Al-Kattan AN (2020) Effects of Quadruple Therapy: Zinc, Quercetin, Bromelain and Vitamin C on the Clinical Outcomes of Patients Infected with COVID-19. Rea Int J of End and Diabe. 1(1): 018-021. DOI: 10.37179/rijed.000005.